In recent years, a special molecule has been increasingly mentioned in aging research: NAD+. According to scientists, this coenzyme plays a key role in how our body ages – and in the condition our skin maintains over time.

NAD+ acts like a power switch for our cells—without it, the mechanisms that produce energy, repair DNA, and support cell health can’t function properly.
When we are young, our body maintains high NAD+ level, which gradually decline as part of the aging process. 
Why optimal NAD+ level is important from a beauty perspective? Because NAD+ is not only a secret of longevity, but also one of the fundamental factors of maintaining youthful, firm, and radiant skin.

What Is NAD+?

NAD+ is a coenzyme—an extremely small molecule present in every single cell of our body. Although it’s invisible from the outside, it’s essential for the proper functioning of both our body and skin.
Imagine our cells as tiny factories: they produce energy, repair damage, and ensure continuous operation. NAD+ acts as the key energy source that drives and sustains these cellular functions.
Among other functions, NAD+:

• supports energy transfer within cells,
• aids DNA repair and regeneration,
• protects the body against inflammation-driven aging,
• contributes to strengthening the skin’s barrier function.

When the NAD+ level is high, cells work more efficiently, making the skin appear younger, firmer, and healthier. When NAD+ level declines—a natural process over time—it becomes one of the key factors of aging.

Why Does NAD+ Decline, and What Does This Mean for the Skin?

Although NAD+ is essential for cellular function, its levels unfortunately do not remain constant. From the late twenties onward, the NAD+ level begins to decrease gradually, and this process accelerates with age.
Several factors can speed up the decline of NAD+ levels:

• Stress and lack of sleep – cells have less time to regenerate
• Environmental aggressors – UV radiation, air pollution, blue light
• Lifestyle factors – poor nutrition, lack of exercise, smoking

When NAD+ levels drop, cells produce energy less efficiently and repair themselves slower. This has visible consequences on the skin:

• wrinkles form and get deeper more quickly,
• skin loses elasticity,
• complexion becomes dull and tired-looking.

In simple terms: the less NAD+ is available to the body, the faster the signs of aging appear.

How Does NAD+ Support the Skin?

The good news is that scientific research shows NAD+ levels can be supported and stimulated, helping the skin maintain its youthful function. When cells once again have access to sufficient NAD+, they perform much more effectively all the tasks related to skin beauty and health.
Benefits of optimal NAD+ levels for the skin include:

• Stimulated cellular regeneration → daily damage is repaired more quickly
• Slowed inflammation-related aging (inflammaging) → more rejuvenated skin
• Improved energy supply → firmer, more vibrant skin
• Support for collagen production and the skin barrier → more elastic, resilient skin with better moisture retention.

In other words: when NAD+ levels are optimal, the skin becomes visibly younger, smoother, and more radiant. This is why NAD+ is considered one of the most promising key molecules in modern pro-aging researches.

 

NAD+ and Longevity – Not Just a Longer Life, but a Better One

When we talk about NAD+, many people immediately think of extending lifespan. Indeed, this coenzyme plays a crucial role in keeping our cells healthy for longer. But longevity—the philosophy of a long, high-quality life—is about much more than simply adding years.

Longevity is about living each day with more energy, freshness, and authenticity. NAD+ plays a central role in this: when our cells function optimally, it positively affects our vitality, well-being—and, of course, the condition of our skin.
The skin is the most visible mirror of what happens inside us. Adequate NAD+ levels not only slow the formation of wrinkles but also help the skin remain radiant, firm, and full of life—exactly as the longevity philosophy promises: a longer and better life, inside and out.

How Has Vagheggi Incorporated NAD+ into the 75.25 Longevity Line?

Vagheggi has always represented the meeting point of nature and science in phytocosmetics. The heart of the 75.25 Longevity line is the NAD+ Activator, chosen specifically for its ability to support cellular energy production and regeneration. Clinical tests prove that with regular use, the skin can appear up to 8.2 years younger.

In addition to the NAD+ Activator, the formulas include Lapacho extract, which protects DNA telomeres, slows cellular aging, and stimulates collagen and hyaluronic acid production. In the 75.25 Longevity Night Cream, Lavandula Hybrida helps resynchronize the skin’s circadian rhythm, allowing cells to regenerate more effectively during sleep. The eye contour product features a bio-fermented peptide that targets wrinkles, puffiness, and dark circles.

What truly makes the Vagheggi Longevity collection unique is the Efficacy Booster device—a high-tech beauty tool that multiplies the effectiveness of the 75.25 Longevity day creamc through a combination of red light, microcurrent, heat, and vibration. This synergy opens a new era in at-home skincare, bringing scientifically proven results directly into your beauty routine.

Daily Beauty Routine with NAD+ – How to Integrate It into Everyday Life

Supporting NAD+ can be both science-driven and a daily beauty ritual. The Vagheggi 75.25 Longevity line was designed to seamlessly fit into everyday routines while working at a cellular level for younger-looking skin.

Morning routine:

• Cleanse your skin with the Longevity double cleanser, which refreshes and prepares the skin.
• Apply the Longevity Day Cream, then use the Efficacy Booster device—just 3 minutes for firmer, more radiant skin.
• Use the Longevity Eye Contour for a lifted and a refreshed look.

Evening routine:

• Remove impurities with the Longevity double cleanser, then refresh the skin with the pre-serum tonic.
• Apply the Longevity Night Cream, which supports nighttime cellular regeneration thanks to Lavandula Hybrida.
• A few times a week, complement your routine with the Longevity exfoliant or the nourishing 3D oil.

Extra treatment:

When your skin feels  tired or stressed, choose the Longevity intensive ampoule treatment—a 10-day course that replenishes the skin at a cellular level with NAD+ Activator.

Frequently Asked Questions About NAD+ and the Vagheggi Longevity Program

What is NAD+, and why is it important for my skin?

NAD+ is a coenzyme present in every cell, playing a key role in energy production, regeneration, and DNA repair. When the NAD+ level is high, cells function more efficiently, helping the skin remain firmer, younger-looking, and more radiant.

When does NAD+ start to decline in the body?

NAD+ levels begin to decrease from the late twenties onward and continue to decline with age. This contributes to visible signs of skin aging, such as wrinkles and loss of elasticity.

How can I support my NAD+ level through skincare?

In addition to a healthy lifestyle—quality sleep, balanced nutrition, stress reduction—the Vagheggi 75.25 Longevity line contains a NAD+ Activator that supports the skin’s natural cellular function and promotes a more youthful appearance.

What makes the Vagheggi Longevity collection different from other Age Care lines?

The Vagheggi 75.25 Longevity line works not only on the skin’s surface but also at a cellular level. The combination of NAD+ Activator, Lapacho extract, and the high-tech Efficacy Booster device delivers noticeably younger-looking, more radiant skin.

How quickly will I notice results when using Vagheggi Longevity products?

Clinical tests show visible improvements in skin firmness and radiance after just 14 days, with regular use delivering long-lasting results.